Her latest comments come in the wake of unease following the unveiling of "AI actor", Tilly Norwood.
Norwood was created by Dutch actor and comedian Eline Van der Velden, who reportedly said she wanted Norwood to become the "next Scarlett Johansson".
In a statement, SAG-Aftra said Norwood "is not an actor, it's a character generated by a computer program that was trained on the work of countless professional performers.
"It has no life experience to draw from, no emotion and, from what we've seen, audiences aren't interested in watching computer-generated content untethered from the human experience," the union added.
Actress Emily Blunt also recently said she found the idea of Norwood terrifying.
"That is really, really scary, Come on, agencies, don't do that. Please stop. Please stop taking away our human connection," she said on a podcast with Variety.
Van der Velden later said in a statement, external: "To those who have expressed anger over the creation of my AI character, Tilly Norwood, she is not a replacement for a human being, but a creative work – a piece of art.
"Like many forms of art before her, she sparks conversation, and that in itself shows the power of creativity."