A Hacker News thread discusses a study about Vitamin C boosting epidermal growth via DNA demethylation. Users debate the implications of the study and whether it translates to real-world benefits. Some users express skepticism, warning against "wellness hacks" and potential health risks from excessive Vitamin C intake. Others point out that the study was done in cell cultures, not on humans, questioning how topical or oral applications would work. The effectiveness of topical Vitamin C serums is discussed, with one user providing detailed information comparing absorption rates and half-lives of oral vs. transdermal Vitamin C application, concluding that topical application is far more effective for targeting the skin. A user also suggests vitamin C cream for skin repair, while another quips about psychotherapy as another option for addressing skin issues related to aging.