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Update (0640ET):

The City of New Orleans has confirmed ten dead and 30 injured after a vehicle plowed into a large crowd on Canal and Bourbon Street.

The New Orleans Police Department has yet to confirm if the mass casualty incident was intentional. 

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The New Orleans Police Department told local media outlet WGNO that multiple people are dead after a vehicle plowed into a crowd on Bourbon Street in the French Quarter. The area, a bar and restaurant district popular with tourists, was still very active just hours after New Year's Eve celebrations.

NOPD said the vehicle struck a group of people around 3:15 a.m. local time at the intersection of Bourbon Street and Iberville

Witnesses told CBS News reporter Kati Weis that a truck crashed into the crowd at "high speeds," adding that the driver exited the vehicle and started discharging a weapon, prompting police officers to return fire.

Unconfirmed video. 

Weis reported that multiple people were on the ground with serious injuries.

NOPD told CBS News that "initial reports show a car may have plowed into a group of people. Injuries are unknown but there are reported fatalities."

*Developing...